Red Blood Cell-san is determined to make it around the entire respiratory system without the help of other cells. After numerous times getting lost and having a guardian angel in White Blood Cell-san help her from the shadows, she finally makes it all the way around for one cycle! Then, we go to a different cell who is in his apartment, dividing himself to make another cell. He finds another cell who is playing practical jokes on white blood cells and Killer T cells. The practical joker turns out to be a rhinovirus, wanting to infect all the cells and cause the Cold. Later, White Blood Cell-san fights tirelessly to help the cells of a hair follicle fight off the bacteria that causes acne. Lots of other white blood cells have tried and failed, but White Blood Cell-san isn’t a quitter!

Vol 4: The Crystal Kingdom by Clint, Griffin, Justin, and Travis McElroy, illustrated by Carey Pietsch

​The trio is on another mission to bring back another relic, a transmutation stone that is acting kind of like King Midas. It's currently on a floating laboratory that is slowly being consumed by pink crystal that transforms everything it touches. With their favorite team of Regulators (including Killian and Carey), they travel to the laboratory in special space suits to keep out any crystal particles that might transform them. They have to find the transmutation stone and save the laboratory before it's engines can't handle the weight and it crashes to the planet below, which will turn all of that into crystal too. Just in case that isn't all too complicated, Kravitz, an agent of Death, tags along to try to right the wrongs of people escaping death, which includes most of the people on the laboratory!

Illustrated by Tarako
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God has a team of designers at his disposal who will make all manner of creatures based on a very limited scope - things like a mammal able to eat leaves off tall trees (which results in a giraffe), or something “adorably uncute” (which results in the koala). The designers, all sharing a name with one of the planets, each have their quirks when designing animals: Mr. Saturn’s greatest invention was the horse, something he tries to reinvent for everyone challenge to limited success; Pluto makes terrifying animals but is also very fixated on how her creations will reproduce; Neptune makes all kinds of amphibious animals; and Jupiter has become the official taste-tester, making sure delicious animals have extra protection or defense mechanisms. At the end of each chapter is a note on the main, real, animals that were designed, providing some educational content for readers.

In this volume’s slices of Tatsu's life: he has tea with a few other housewives and, while he’s recounting his time in the mob, they think he’s talking about his wife, Miku, and think she's hardcore; he helps a young boy with his summer assignments and goes a bit overboard; he gets Masa set up with a bunch of household gadgets from the 100 yen store; a cat burlgar (an actual cat) steals a fish from Tatsu and he gives chase; and Tatsu and Miku go to an amusement park but get rained out halfway through their day.

Vol 3: Petals to the Metal! by Clint, Griffin, Justin, and Travis McElroy, illustrated by Carey Pietsch

The trio is back on another assignment, this time to find the Gaia Sash, which has been put to use by a thief named Raven who has holed up in a vault in the city of Goldcliff. The three meet a local cop, Hurley, who has a connection with Raven and might be able to help them slow her down. Hurley and Raven were racing teammates in the highly dangerous Battlewagon races that are super popular (and super illegal) in Goldcliff. Raven escapes the tower, but Hurley knows Raven will be in the next Battlewagon race. The only way to get to Raven is for the three heroes and Hurley to form a new battlewagon team and try to take her down in the race, and watch out for the twelve other teams trying to take down and beat them!

Eniale and Dewiel are an angel and demon, respectively, who are often at odds with each other on borrowing one another’s makeup without asking, or gathering souls for their employers. In one of their apocalyptic fights, they find a baby and search for its mother using means that send humanity into a panic. After destroying their clothes in another fight, the two travel to Paris to replenish their wardrobe, and an exorcist discerns and chases after Dewi relentlessly. A little girl summons both the angel and demon to help her sick mother recover, and it’s a competition to see who can win the little girl over to “their side.” After Eni pisses her friend off completely, Dewi “helps” Eni build the “perfect” hot springs and vows to drain Eni’s seemingly endless supply of money.

Anya is still on the mission to get Stella Stars, and the upcoming midterms will offer her many opportunities to win them if she can get top marks on her tests. But, her power to read minds will be weakest during midterms. She’ll actually have to study! “Uncle” Yuri comes over to help her study, but quickly gives up in frustration. Yor is meanwhile trying to be a better wife and takes some cooking lessons to help make edible food that won’t make her family sick. Later, Anya’s school assigns a report for students to explore a profession they might want to pursue, and Anya chooses to shadow Loid at his cover job as a hospital psychiatrist. Then, NIghtfall, another spy from The Agency, believes she would make a better wife to Twilight in real life and his assignment, and is determined to find Yor's weaknesses and exploit them.

Hana is a precocious young girl who doesn’t usually do as she’s told and has many adventures with her friends. First, Hana prepares her emergency “rations” of choco-puffs, which she leaves at her school. When a typhoon hits her town, she takes her cat down to her school to retrieve the rations in the storm. In another adventure, Hana and her friend sit in an abandoned VW Bug, when a dam breaks and carries them downstream to the sea. Later, Hana gets stuck in a hammock and her friends have to get her out before a corporation, bent on reclaiming some derelict fields, torch the whole place and Hana along with it.  

The cells are still hard at work, this time against a few different attackers. First, the blood cells have to fight off food poisoning from bacteria but also a tape worm hidden inside sushi, and it threatens to break through the stomach wall! Next, the body undergoes heat stress, which makes it difficult to fight off bacteria, especially ones that have their own heat protection. Red Blood Cell gets lost on a delivery (again) and finds herself in the Bone Marrow where red and white blood cells are nurtured through their young lives before they become mature red or white blood cells. This detour takes Red Blood Cell down memory lane, to her own upbringing. Lastly, the immune system must fight off the deadly, mutated cancer cells that trick the body into bringing it nutrients so it can multiply faster.

A little while ago, an octopus-like alien took a giant chunk out of the moon.  He's sent the world into chaos, and has promised to do the same to the Earth.  He can fly and move at Mach 20, and traditional weapons do hardly any damage against him even if they do connect.  He's decided to settle on Earth for the time being, and has asked to become the teacher of Class 3-E at a middle school - the class of all the academically struggling, misfit, not-involved students who are critically behind their peers school-wise.  Since Koro-Sensei (as the students name him based on a pun meaning "can't be killed) is stationery to the classroom, the government has deputized all of the students in 3-E and given them one mission: kill their teacher before graduation, the date he plans on destroying the Earth.  But, Koro-Sensei also cares deeply about each one of his students, as he connects with them personally and tries to beef up their academic skills.  Some of the students have reservations about trying to kill one of the most caring teachers they've ever had.  That's until another student rejoins the class -- one who's been out on suspension for violence, and who has a disturbing dream of killing a teacher.